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HRas
Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Belongs to the small GTPase superfamily. Ras family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 7 F5|7 86.48 cM |
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Cellular Component:
cytosol; glutamatergic synapse; Golgi apparatus; GTPase complex; membrane; nucleoplasm; plasma membrane
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Molecular Function:
G protein activity; GDP binding; GTP binding; GTPase activity; hydrolase activity; nucleotide binding; protein binding; protein-containing complex binding; protein-membrane adaptor activity
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Biological Process:
adipose tissue development; cellular response to gamma radiation; cellular senescence; defense response to protozoan; endocytosis; fibroblast proliferation; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; intrinsic apoptotic signaling pathway; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of GTPase activity; negative regulation of neuron apoptotic process; neuron apoptotic process; oncogene-induced cell senescence; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of miRNA metabolic process; positive regulation of phospholipase C activity; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of Ras protein signal transduction; positive regulation of ruffle assembly; positive regulation of transcription by RNA polymerase II; positive regulation of type II interferon production; positive regulation of wound healing; Ras protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell cycle; regulation of cell population proliferation; regulation of long-term neuronal synaptic plasticity; regulation of MAP kinase activity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of transcription by RNA polymerase II; signal transduction; small GTPase mediated signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
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Reference #:
Q61411
(UniProtKB)
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Alt. Names/Synonyms: c-H-; c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-r; c-rasHa; GTPase HRas; GTPase HRas, N-terminally processed; H-ras; H-Ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harv; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hra; Hras; Hras-1; Hras1; Kras2; OTTMUSP00000017718; OTTMUSP00000017719; p21ras; ras; RASH; Transforming protein p21
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Gene Symbols: Hras
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Molecular weight:
21,298 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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NF-kB Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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