HRas Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Belongs to the small GTPase superfamily. Ras family. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of human Ortholog: 11p15.5
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum membrane; glutamatergic synapse; Golgi apparatus; Golgi membrane; GTPase complex; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  G protein activity; GDP binding; GTP binding; GTPase activity; protein binding; protein-membrane adaptor activity
Biological Process:  adipose tissue development; animal organ morphogenesis; cell surface receptor signaling pathway; cellular response to gamma radiation; cellular senescence; chemotaxis; defense response to protozoan; endocytosis; fibroblast proliferation; insulin receptor signaling pathway; intrinsic apoptotic signaling pathway; MAPK cascade; negative regulation of cell population proliferation; negative regulation of gene expression; negative regulation of GTPase activity; negative regulation of neuron apoptotic process; neuron apoptotic process; oncogene-induced cell senescence; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of miRNA metabolic process; positive regulation of phospholipase C activity; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of ruffle assembly; positive regulation of transcription by RNA polymerase II; positive regulation of type II interferon production; positive regulation of wound healing; Ras protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell cycle; regulation of cell population proliferation; regulation of long-term neuronal synaptic plasticity; regulation of MAP kinase activity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of transcription by RNA polymerase II; signal transduction; T cell receptor signaling pathway; T-helper 1 type immune response
Disease: Bladder Cancer; Costello Syndrome; Melanocytic Nevus Syndrome, Congenital; Nevus, Epidermal; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular
Reference #:  P01112 (UniProtKB)
Alt. Names/Synonyms: C-BAS/HAS; c-H-ras; C-HA-RAS1; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; GTPase HRas, N-terminally processed; H-Ras; H-Ras-1; H-RASIDX; Ha-Ras; Ha-Ras1 proto-oncoprotein; HAMSV; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; HRAS; HRas proto-oncogene, GTPase; HRAS1; K-RAS; N-RAS; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; RASH; RASH1; transformation gene: oncogene HAMSV; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Gene Symbols: HRAS
Molecular weight: 21,298 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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HRas

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein