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LAIR-1
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 19q13.42 |
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Cellular Component:
integral component of membrane; plasma membrane; specific granule membrane; tertiary granule membrane
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Molecular Function:
protein binding
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Biological Process:
adaptive immune response; neutrophil degranulation; regulation of immune response
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Reference #:
Q6GTX8
(UniProtKB)
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Alt. Names/Synonyms: CD305; hLAIR1; immunoglobulin heavy chain variable region; LAIR-1; LAIR1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; Leukocyte-associated immunoglobulin-like receptor 1
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Gene Symbols: LAIR1
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Molecular weight:
31,412 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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