TBCB Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Belongs to the TBCB family. Found in most tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component:  cytoplasm; cytosol; microtubule; microtubule cytoskeleton
Molecular Function:  protein binding
Biological Process:  cell differentiation; nervous system development
Reference #:  Q99426 (UniProtKB)
Alt. Names/Synonyms: CG22; CKAP1; CKAPI; cytoskeleton associated protein 1; Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; MGC14625; TBCB; tubulin folding cofactor B; Tubulin-folding cofactor B; Tubulin-specific chaperone B
Gene Symbols: TBCB
Molecular weight: 27,326 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
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TBCB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene