TUBB Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p21.33
Cellular Component:  azurophil granule lumen; cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; extracellular region; membrane raft; microtubule; nuclear envelope lumen
Molecular Function:  GTPase activating protein binding; GTPase activity; MHC class I protein binding; protein binding; protein domain specific binding; protein-containing complex binding; structural molecule activity; ubiquitin protein ligase binding
Biological Process:  cell division; cellular process; ciliary basal body-plasma membrane docking; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based process; natural killer cell mediated cytotoxicity; neutrophil degranulation; regulation of G2/M transition of mitotic cell cycle; regulation of synapse organization; spindle assembly
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 6; Skin Creases, Congenital Symmetric Circumferential, 1
Reference #:  P07437 (UniProtKB)
Alt. Names/Synonyms: beta 5-tubulin; beta Ib tubulin; beta-4 tubulin; CDCBM6; CSCSC1; epididymis secretory sperm binding protein; M40; MGC117247; MGC16435; OK/SW-cl.56; TBB5; TUBB; TUBB1; TUBB5; Tubulin beta chain; tubulin beta class I; tubulin beta polypeptide; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, beta; tubulin, beta polypeptide
Gene Symbols: TUBB
Molecular weight: 49,671 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene