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TUBB
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
azurophil granule lumen; cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; extracellular region; intercellular bridge; membrane raft; microtubule; microtubule cytoskeleton; mitotic spindle; nuclear envelope lumen; protein-containing complex
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Molecular Function:
GTP binding; GTPase activating protein binding; GTPase activity; metal ion binding; MHC class I protein binding; protein binding; protein domain specific binding; protein-containing complex binding; structural constituent of cytoskeleton; structural molecule activity; ubiquitin protein ligase binding
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Biological Process:
cell division; cytoskeleton-dependent intracellular transport; microtubule cytoskeleton organization; microtubule-based process; mitotic cell cycle; natural killer cell mediated cytotoxicity; odontoblast differentiation; regulation of synapse organization; spindle assembly
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Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 6; Skin Creases, Congenital Symmetric Circumferential, 1
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Reference #:
P07437
(UniProtKB)
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Alt. Names/Synonyms: beta 5-tubulin; beta Ib tubulin; beta-4 tubulin; CDCBM6; CSCSC1; epididymis secretory sperm binding protein; M40; MGC117247; MGC16435; OK/SW-cl.56; TBB5; TUBB; TUBB1; TUBB5; Tubulin beta chain; tubulin beta class I; tubulin beta polypeptide; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, beta; tubulin, beta polypeptide
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Gene Symbols: TUBB
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Molecular weight:
49,671 Da
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Basal Isoelectric point:
4.78
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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