DBNL Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Belongs to the ABP1 family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p13
Cellular Component:  cell cortex; cell junction; clathrin-coated vesicle membrane; cytoplasm; cytosol; dendrite; early endosome; extracellular region; ficolin-1-rich granule lumen; Golgi membrane; lamellipodium; plasma membrane; podosome; postsynaptic density; ruffle; secretory granule lumen; tertiary granule lumen
Molecular Function:  actin binding; actin filament binding; enzyme activator activity; protein binding; protein C-terminus binding; protein domain specific binding
Biological Process:  activation of JUN kinase activity; adaptive immune response; neuron projection morphogenesis; neutrophil degranulation; podosome assembly; Rac protein signal transduction; receptor-mediated endocytosis; ruffle assembly; synapse assembly
Reference #:  Q9UJU6 (UniProtKB)
Alt. Names/Synonyms: ABP1; Cervical mucin-associated protein; Cervical SH3P7; CMAP; DBNL; Drebrin-F; drebrin-like; Drebrin-like protein; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; SH3P7; src homology 3 domain-containing protein HIP-55
Gene Symbols: DBNL
Molecular weight: 48,207 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DBNL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein