DOCK2 a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component:  cytoskeleton; cytosol; extracellular region; specific granule lumen
Molecular Function:  GTPase activator activity; protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process:  actin cytoskeleton organization; alpha-beta T cell proliferation; chemotaxis; establishment of T cell polarity; immunological synapse formation; macropinocytosis; membrane raft polarization; myeloid dendritic cell activation involved in immune response; negative thymic T cell selection; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of phagocytosis; positive thymic T cell selection; regulation of defense response to virus by virus; small GTPase mediated signal transduction
Disease: Immunodeficiency 40
Reference #:  Q92608 (UniProtKB)
Alt. Names/Synonyms: dedicator of cyto-kinesis 2; dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK2; FLJ46592; KIAA0209
Gene Symbols: DOCK2
Molecular weight: 211,948 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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