DOCK2 Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Belongs to the DOCK family. Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component:  cytoskeleton; cytosol; extracellular region; specific granule lumen
Molecular Function:  GTPase activator activity; protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process:  actin cytoskeleton organization; alpha-beta T cell proliferation; chemotaxis; establishment of T cell polarity; immunological synapse formation; macropinocytosis; membrane raft polarization; myeloid dendritic cell activation involved in immune response; negative thymic T cell selection; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of phagocytosis; positive thymic T cell selection; regulation of defense response to virus by virus; small GTPase mediated signal transduction
Disease: Immunodeficiency 40
Reference #:  Q92608 (UniProtKB)
Alt. Names/Synonyms: dedicator of cyto-kinesis 2; dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK2; FLJ46592; KIAA0209
Gene Symbols: DOCK2
Molecular weight: 211,948 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene