DCP1B May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Belongs to the DCP1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.-.-.-; Hydrolase; RNA-binding
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component:  cytosol; intracellular membrane-bounded organelle; nucleus
Molecular Function:  enzyme activator activity; hydrolase activity; protein binding
Biological Process:  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity
Reference #:  Q8IZD4 (UniProtKB)
Alt. Names/Synonyms: DCP1; DCP1 decapping enzyme homolog B; DCP1 decapping enzyme homolog B (S. cerevisiae); DCP1B; decapping enzyme hDcp1b; decapping mRNA 1B; hDcp1b; mRNA-decapping enzyme 1B
Gene Symbols: DCP1B
Molecular weight: 67,723 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DCP1B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB