DCP1B
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Belongs to the DCP1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.-.-.-; Hydrolase; RNA-binding |
Chromosomal Location of Human Ortholog: 12p13.33 |
Cellular Component:
cytosol; intracellular membrane-bounded organelle; nucleus
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Molecular Function:
enzyme activator activity; hydrolase activity; protein binding
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Biological Process:
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity
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Reference #:
Q8IZD4
(UniProtKB)
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Alt. Names/Synonyms: DCP1; DCP1 decapping enzyme homolog B; DCP1 decapping enzyme homolog B (S. cerevisiae); DCP1B; decapping enzyme hDcp1b; decapping mRNA 1B; hDcp1b; mRNA-decapping enzyme 1B
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Gene Symbols: DCP1B
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Molecular weight:
67,723 Da
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Basal Isoelectric point:
8.75
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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