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ABRAXAS2
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. Belongs to the FAM175 family. Abro1 subfamily. Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain (PubMed:21195082). Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 10q26.13 |
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Cellular Component:
BRISC complex; centrosome; cytoplasm; cytosol; microtubule minus-end; midbody; nucleus; spindle pole centrosome
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Molecular Function:
microtubule binding; polyubiquitin modification-dependent protein binding; protein binding
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Biological Process:
attachment of spindle microtubules to kinetochore; cell division; chromosome segregation; mitotic cell cycle; mitotic spindle assembly; protein K63-linked deubiquitination; response to ischemia
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Reference #:
Q15018
(UniProtKB)
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Alt. Names/Synonyms: abraxas 2, BRISC complex subunit; abraxas brother 1; Abraxas brother protein 1; ABRAXAS2; ABRO1; ABRX2; BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; F175B; FAM175B; family with sequence similarity 175 member B; family with sequence similarity 175, member B; FLJ22338; KIAA0157; Protein FAM175B
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Gene Symbols: ABRAXAS2
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Molecular weight:
46,901 Da
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Basal Isoelectric point:
5.83
Predict pI for various phosphorylation states
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