VIPAS39 Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin. Belongs to the SPE39 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 14q24.3
Cellular Component:  cytoplasm; early endosome; endosome; Golgi apparatus; HOPS complex; late endosome; recycling endosome; vesicle tethering complex
Molecular Function:  protein binding; protein-containing complex binding
Biological Process:  autophagosome maturation; cell differentiation; collagen fibril organization; collagen metabolic process; endosome to lysosome transport; intracellular protein transport; intracellular transport; peptidyl-lysine hydroxylation; phagosome-lysosome fusion; post-translational protein modification; spermatogenesis; vacuolar transport
Disease: Arthrogryposis, Renal Dysfunction, And Cholestasis 2
Reference #:  Q9H9C1 (UniProtKB)
Alt. Names/Synonyms: C14orf133; CN133; FLJ12707; hSPE-39; SPE-39; SPE-39 protein; SPE39; Spermatogenesis-defective protein 39 homolog; VIPAR; VIPAS39; VPS16B; VPS33B interacting protein, apical-basolateral polarity regulator; VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; VPS33B-interacting protein involved in polarity and apical protein restriction
Gene Symbols: VIPAS39
Molecular weight: 57,005 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein