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DBN1
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus. Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578). Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578). Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578). Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400). Expressed in the brain (PubMed:8216329, Ref.2). Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
actin cytoskeleton; actin filament; actomyosin; cortical actin cytoskeleton; cortical cytoskeleton; cytoplasm; cytoskeleton; dendrite; gap junction; glutamatergic synapse; growth cone; lamellipodium; plasma membrane; postsynaptic cytosol; postsynaptic density; postsynaptic membrane; site of polarized growth
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Molecular Function:
actin binding; actin filament binding; profilin binding; protein binding
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Biological Process:
actin filament organization; cell communication by chemical coupling; cell communication by electrical coupling; cytoplasmic sequestering of protein; in utero embryonic development; maintenance of protein location in cell; neural precursor cell proliferation; neuron projection morphogenesis; positive regulation of axon extension; positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; positive regulation of synaptic plasticity; postsynaptic actin cytoskeleton organization; regulation of actin filament polymerization; regulation of dendrite development; regulation of neuronal synaptic plasticity
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Reference #:
Q16643
(UniProtKB)
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Alt. Names/Synonyms: D0S117E; DBN1; Developmentally-regulated brain protein; DKFZp434D064; DREB; Drebrin; drebrin 1; drebrin A; drebrin E; drebrin E2; drebrin-1
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Gene Symbols: DBN1
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Molecular weight:
71,429 Da
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Basal Isoelectric point:
4.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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