DBN1 a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  actin cytoskeleton; actomyosin; cortical cytoskeleton; cytoplasm; cytoskeleton; dendrite; gap junction; glutamatergic synapse; growth cone; postsynaptic cytosol; postsynaptic density; postsynaptic membrane
Molecular Function:  actin binding; profilin binding; protein binding
Biological Process:  actin filament organization; cell communication by chemical coupling; cell communication by electrical coupling; cytoplasmic sequestering of protein; maintenance of protein location in cell; neural precursor cell proliferation; positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; positive regulation of synaptic plasticity; regulation of dendrite development; regulation of neuronal synaptic plasticity
Reference #:  Q16643 (UniProtKB)
Alt. Names/Synonyms: D0S117E; DBN1; Developmentally-regulated brain protein; DKFZp434D064; DREB; Drebrin; drebrin 1; drebrin E; drebrin E2; drebrin-1
Gene Symbols: DBN1
Molecular weight: 71,429 Da
Basal Isoelectric point: 4.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein