BDP1 Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Expressed in brain, colon and several tumor-derived cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein tyrosine phosphatase activity
Biological Process:  blastocyst formation; cellular response to cytokine stimulus; ERBB2 signaling pathway; negative regulation of ERBB signaling pathway; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q99952 (UniProtKB)
Alt. Names/Synonyms: BDP1; Brain-derived phosphatase; protein tyrosine phosphatase non-receptor type 18; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); PTN18; PTP-HSCF; PTPN18; Tyrosine-protein phosphatase non-receptor type 18
Gene Symbols: PTPN18
Molecular weight: 50,482 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BDP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein