GIT2 possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component:  nucleoplasm
Molecular Function:  GTPase activator activity; metal ion binding; protein binding
Biological Process:  positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
Reference #:  Q14161 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT2; ARF GTPase-activating protein GIT2; CAT-2; CAT2; cool-associated, tyrosine phosphorylated protein 2; Cool-interacting tyrosine-phosphorylated protein 2; DKFZp686G01261; G protein-coupled receptor kinase interacting ArfGAP 2; G protein-coupled receptor kinase interactor 2; G protein-coupled receptor kinase-interactor 2; GIT2; GRK-interacting protein 2; KIAA0148; MGC760
Gene Symbols: GIT2
Molecular weight: 84,543 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein