PAG Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q21.13
Cellular Component:  integral component of membrane; membrane raft; plasma membrane
Molecular Function:  protein binding; SH2 domain binding; SH3/SH2 adaptor activity
Biological Process:  adaptive immune response; intracellular signal transduction; positive regulation of signal transduction; regulation of T cell activation; signal transduction; T cell receptor signaling pathway
Reference #:  Q9NWQ8 (UniProtKB)
Alt. Names/Synonyms: CBP; Csk-binding protein; FLJ37858; MGC138364; PAG; PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp
Gene Symbols: PAG1
Molecular weight: 46,981 Da
Basal Isoelectric point: 4.57  Predict pI for various phosphorylation states
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PAG

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene