ARHGEF2 a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  bicellular tight junction; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; dendritic shaft; glutamatergic synapse; Golgi apparatus; microtubule; neuronal cell body; podosome; postsynaptic density, intracellular component; protein-containing complex; ruffle membrane; spindle; vesicle
Molecular Function:  microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding; zinc ion binding
Biological Process:  actin filament organization; asymmetric neuroblast division; cell morphogenesis; cellular hyperosmotic response; cellular response to muramyl dipeptide; cellular response to tumor necrosis factor; establishment of mitotic spindle orientation; G protein-coupled receptor signaling pathway; innate immune response; intracellular protein transport; intracellular signal transduction; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of microtubule depolymerization; negative regulation of necroptotic process; negative regulation of neurogenesis; negative regulation of podosome assembly; positive regulation of apoptotic process; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of neuron migration; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Disease: Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Reference #:  Q92974 (UniProtKB)
Alt. Names/Synonyms: ARHG2; ARHGEF2; DKFZp547L106; DKFZp547P1516; FLJ45440; GEF; GEF-H1; GEFH1; Guanine nucleotide exchange factor H1; KIAA0651; LFP40; Microtubule-regulated Rho-GEF; P40; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2; RhoGEF2
Gene Symbols: ARHGEF2
Molecular weight: 111,543 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein