PIKFYVE The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 2q34
Cellular Component:  cell-cell junction; cytosol; early endosome membrane; endosome membrane; Golgi membrane; late endosome membrane; membrane raft; perinuclear region of cytoplasm; vesicle membrane
Molecular Function:  1-phosphatidylinositol-3-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; protein binding; zinc ion binding
Biological Process:  intracellular signal transduction; myelin assembly; phosphatidylinositol 5-phosphate metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; protein localization to nucleus; regulation of autophagosome assembly; retrograde transport, endosome to Golgi
Disease: Corneal Dystrophy, Fleck
Reference #:  Q9Y2I7 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; CFD; epididymis luminal protein 37; FAB1; FLJ37746; FYV1; FYVE finger-containing phosphoinositide kinase; HEL37; KIAA0981; MGC40423; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; Phosphatidylinositol-3-phosphate 5-kinase; Phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; phosphoinositide kinase, FYVE-type zinc finger containing; PIKFYVE; PIP5K; PIP5K3; PIPkin-III; PtdIns(4)P-5-kinase; Type III PIP kinase; ZFYVE29; zinc finger, FYVE domain containing 29
Gene Symbols: PIKFYVE
Molecular weight: 237,136 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein