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NRAGE
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: Xp11.22 |
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Cellular Component:
chromatin; cytosol; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
identical protein binding; protein binding; transcription coactivator activity
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Biological Process:
circadian regulation of gene expression; negative regulation of epithelial cell proliferation; negative regulation of protein localization to nucleus; negative regulation of transcription by RNA polymerase II; positive regulation of apoptotic signaling pathway; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of DNA-templated transcription; positive regulation of MAP kinase activity; protein localization to nucleus; regulation of apoptotic process; regulation of circadian rhythm; regulation of DNA-templated transcription
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Reference #:
Q9Y5V3
(UniProtKB)
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Alt. Names/Synonyms: DLXIN-1; MAGD1; MAGE family member D1; MAGE tumor antigen CCF; MAGE-D1 antigen; MAGED1; melanoma antigen family D, 1; melanoma antigen family D1; Melanoma-associated antigen D1; Neurotrophin receptor-interacting MAGE homolog; NRAGE
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Gene Symbols: MAGED1
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Molecular weight:
86,161 Da
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Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
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