ARHGAP5 GTPase-activating protein for Rho family members. Detected in skin fibroblasts (at protein level) (PubMed:8537347). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q12
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; plasma membrane
Molecular Function:  GTP binding; GTPase activator activity; GTPase activity; protein binding; SH2 domain binding
Biological Process:  cell adhesion; mammary gland development; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  Q13017 (UniProtKB)
Alt. Names/Synonyms: ARHGAP5; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 RhoGAP; p190-B; p190BRhoGAP; RHG05; Rho GTPase activating protein 5; Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; RHOGAP5
Gene Symbols: ARHGAP5
Molecular weight: 172,460 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARHGAP5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein