CLIM1 a cytoskeletal adaptor protein that bring other proteins to the cytoskeleton. Interacts with alpha-actinins 1, 2 and 4. Recruits the Clik1 kinase to actin stress fibers in nonmuscle cells. Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component:  cytoskeleton; transcription factor complex; Z disc
Molecular Function:  metal ion binding; transcription coactivator activity
Biological Process:  regulation of transcription, DNA-templated; response to hypoxia; response to oxidative stress
Reference #:  O00151 (UniProtKB)
Alt. Names/Synonyms: C-terminal LIM domain protein 1; carboxy terminal LIM domain protein 1; carboxyl terminal LIM domain protein 1; CLIM1; CLP-36; CLP36; Elfin; enigma; hCLIM1; LIM domain protein CLP-36; PDLI1; PDLIM1; PDZ and LIM domain 1; PDZ and LIM domain protein 1
Gene Symbols: PDLIM1
Molecular weight: 36,072 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
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CLIM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene