IRAP a leucyl/cystinyl aminopeptidase. A type II membrane protein and secreted. Resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin.. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 5q15
Cellular Component:  cytoplasmic vesicle membrane; cytosol; early endosome lumen; extracellular region; integral component of plasma membrane; perinuclear region of cytoplasm
Molecular Function:  aminopeptidase activity; metallopeptidase activity; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cell-cell signaling; female pregnancy; negative regulation of cold-induced thermogenesis; protein catabolic process; protein polyubiquitination; SMAD protein signal transduction
Reference #:  Q9UIQ6 (UniProtKB)
Alt. Names/Synonyms: angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; insulin-regulated aminopeptidase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; LCAP; Leucyl-cystinyl aminopeptidase; Leucyl-cystinyl aminopeptidase, pregnancy serum form; leucyl/cystinyl aminopeptidase; LNPEP; OTASE; Oxytocinase; P-LAP; Placental leucine aminopeptidase; PLAP; vasopressinase
Gene Symbols: LNPEP
Molecular weight: 117,349 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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