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GAB1 iso2
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Belongs to the GAB family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 4q31.21 |
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Cellular Component:
cell-cell junction; cytoplasm; cytosol
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Molecular Function:
protein binding; signaling adaptor activity
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Biological Process:
angiogenesis; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; response to hepatocyte growth factor; signal transduction; vascular endothelial growth factor signaling pathway
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Reference #:
Q13480-2
(UniProtKB)
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Alt. Names/Synonyms: deafness, autosomal recessive 26; DFNB26; GAB1; GAB1 iso2; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; symbol withdrawn, see GAB1
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Gene Symbols: GAB1
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Molecular weight:
80,005 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Insulin Receptor Signaling
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PI3K/Akt Signaling
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