GAB1 iso2 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Belongs to the GAB family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q31.21
Cellular Component:  cytosol
Molecular Function:  protein binding; SH3/SH2 adaptor activity
Biological Process:  actin cytoskeleton reorganization; angiogenesis; axon guidance; endothelial cell chemotaxis to vascular endothelial growth factor; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; insulin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; response to hepatocyte growth factor; vascular endothelial growth factor signaling pathway
Reference #:  Q13480-2 (UniProtKB)
Alt. Names/Synonyms: GAB1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1
Gene Symbols: GAB1
Molecular weight: 80,005 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling
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GAB1 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein