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OASL
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nucleolus |
| Chromosomal Location of human Ortholog: 12q24.31 |
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Cellular Component:
cytoplasm; cytosol; membrane; nucleolus; nucleoplasm
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Molecular Function:
2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; nuclear thyroid hormone receptor binding; protein binding
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Biological Process:
defense response to virus; innate immune response; interleukin-27-mediated signaling pathway; negative regulation of viral genome replication; positive regulation of RIG-I signaling pathway; regulation of ribonuclease activity; response to virus
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Reference #:
Q15646
(UniProtKB)
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Alt. Names/Synonyms: 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-oligoadenylate synthetase like; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14
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Gene Symbols: OASL
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Molecular weight:
59,226 Da
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Basal Isoelectric point:
7.96
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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