OASL Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleoplasm
Molecular Function:  ATP binding; DNA binding; double-stranded RNA binding; protein binding; thyroid hormone receptor binding
Biological Process:  defense response to virus; interferon-gamma-mediated signaling pathway; negative regulation of viral genome replication; response to virus; type I interferon signaling pathway
Reference #:  Q15646 (UniProtKB)
Alt. Names/Synonyms: 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-oligoadenylate synthetase like; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14
Gene Symbols: OASL
Molecular weight: 59,226 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein