RP1 shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. Its function is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 18q12.1-q12.2
Cellular Component:  focal adhesion; microtubule cytoskeleton
Molecular Function:  identical protein binding; microtubule binding; protein binding; protein kinase binding
Biological Process:  cell division; positive regulation of adherens junction organization; positive regulation of ARF protein signal transduction; positive regulation of GTPase activity; positive regulation of keratinocyte migration
Disease: Skin Creases, Congenital Symmetric Circumferential, 2
Reference #:  Q15555 (UniProtKB)
Alt. Names/Synonyms: APC-binding protein EB1; APC-binding protein EB2; EB1; EB2; End-binding protein 2; MAPRE2; MARE2; Microtubule-associated protein RP/EB family member 2; microtubule-associated protein, RP/EB family, member 2; RP1; T-cell activation protein, EB1 family
Gene Symbols: MAPRE2
Molecular weight: 37,031 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB