PIH1D1 Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex. Belongs to the PIH1 family. Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component:  cytoplasm; nucleolus; nucleus; pre-snoRNP complex; R2TP complex
Molecular Function:  ATPase binding; histone binding; phosphoprotein binding; protein binding; protein kinase binding; RNA polymerase I CORE element sequence-specific DNA binding
Biological Process:  box C/D snoRNP assembly; chromatin remodeling; epithelial cell differentiation; establishment of protein localization to chromatin; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of histone H3-K9 dimethylation; negative regulation of histone H3-K9 trimethylation; negative regulation of histone H4-K16 acetylation; positive regulation of glucose mediated signaling pathway; positive regulation of histone H3-K9 acetylation; positive regulation of histone H4 acetylation; positive regulation of protein complex assembly; positive regulation of protein serine/threonine kinase activity; positive regulation of TORC1 signaling; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of histone H3-K4 methylation; RNA polymerase I preinitiation complex assembly; snoRNA localization
Reference #:  Q9NWS0 (UniProtKB)
Alt. Names/Synonyms: FLJ20643; NOP17; Nucleolar protein 17 homolog; PIH1 domain containing 1; PIH1 domain-containing protein 1; PIH1D1; PIHD1
Gene Symbols: PIH1D1
Molecular weight: 32,363 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
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PIH1D1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene