NUDE1 Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Belongs to the nudE family. Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding
Chromosomal Location of Human Ortholog: 16p13.11
Cellular Component:  centrosome; cleavage furrow; condensed chromosome kinetochore; cytosol; kinetochore; microtubule; spindle pole centrosome; synapse
Molecular Function:  identical protein binding; microtubule binding; protein binding; protein domain specific binding
Biological Process:  cell division; centrosome duplication; cerebral cortex development; ciliary basal body-plasma membrane docking; establishment of chromosome localization; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; neuroblast proliferation; neuron migration; regulation of G2/M transition of mitotic cell cycle; regulation of microtubule motor activity
Disease: Lissencephaly 4; Microhydranencephaly
Reference #:  Q9NXR1 (UniProtKB)
Alt. Names/Synonyms: FLJ20101; HOM-TES-87; LIS1-interacting protein NUDE1, rat homolog; NDE1; Nuclear distribution protein nudE homolog 1; NUDE; nudE nuclear distribution gene E homolog 1 (A. nidulans); NUDE1
Gene Symbols: NDE1
Molecular weight: 38,808 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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