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TRIP4
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 15q22.31 |
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Cellular Component:
activating signal cointegrator 1 complex; centrosome; cytoplasm; cytosol; neuromuscular junction; nuclear body; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
histone acetyltransferase binding; nuclear estrogen receptor binding; nuclear receptor binding; protease binding; protein binding; protein kinase binding; transcription coactivator activity; ubiquitin-like protein ligase binding; zinc ion binding
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Biological Process:
intracellular estrogen receptor signaling pathway; positive regulation of DNA-templated transcription; regulation of DNA-templated transcription; regulation of myoblast differentiation; rescue of stalled ribosome; ribosome disassembly; ribosome-associated ubiquitin-dependent protein catabolic process
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Disease: Muscular Dystrophy, Congenital, Davignon-chauveau Type; Spinal Muscular Atrophy With Congenital Bone Fractures 1
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Reference #:
Q15650
(UniProtKB)
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Alt. Names/Synonyms: Activating signal cointegrator 1; ASC-1; ASC1; HsT17391; MDCDC; SMABF1; thyroid hormone receptor interactor 4; thyroid receptor interacting protein 4; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4; TRIP4; ZC2HC5; zinc finger, C2HC5-type
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Gene Symbols: TRIP4
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Molecular weight:
66,146 Da
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Basal Isoelectric point:
8.05
Predict pI for various phosphorylation states
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