CENTB1 GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  recycling endosome membrane
Molecular Function:  GTPase activator activity; metal ion binding; protein binding
Biological Process:  positive regulation of GTPase activity; protein transport
Reference #:  Q15027 (UniProtKB)
Alt. Names/Synonyms: ACAP1; Arf GAP with coiled coil, ANK repeat and PH domains 1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; centaurin, beta 1; Centaurin-beta-1; CENTB1; Cnt-b1; KIAA0050
Gene Symbols: ACAP1
Molecular weight: 81,536 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
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CENTB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene