GIT1 GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 17q11.2
Cellular Component:  calyx of Held; centrosome; cytosol; focal adhesion; lamellipodium; mitochondrion; mitotic spindle pole; neuron projection; postsynapse; postsynaptic density; synapse
Molecular Function:  gamma-tubulin binding; GTPase activator activity; metal ion binding; protein binding; protein-containing complex binding; small GTPase binding
Biological Process:  brain development; cell redox homeostasis; cellular response to lipopolysaccharide; ephrin receptor signaling pathway; intramembranous ossification; locomotory behavior; motor learning; negative regulation of glycolytic process; negative regulation of inflammatory response to wounding; negative regulation of interleukin-1 beta production; neuron development; positive regulation of microtubule nucleation; presynaptic modulation of chemical synaptic transmission; regulation of ARF protein signal transduction; regulation of cytokinesis; regulation of G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis; synaptic vesicle recycling
Reference #:  Q9Y2X7 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase interactor 1; G protein-coupled receptor kinase-interactor 1; GIT ArfGAP 1; GIT1; GRK-interacting protein 1
Gene Symbols: GIT1
Molecular weight: 84,341 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GIT1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein