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SIT
a low molecular weight transmembrane adaptor protein. A disulfide-linked homodimer. Expressed in lymphocytes. Following phosphorylation by Src and possibly Tec kinases, recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif (ITIM). Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 9p13.3 |
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Cellular Component:
integral component of plasma membrane; plasma membrane
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Molecular Function:
kinase binding; protein binding; SH2 domain binding
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Biological Process:
adaptive immune response; regulation of T cell activation; signal transduction; T cell homeostasis
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Reference #:
Q9Y3P8
(UniProtKB)
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Alt. Names/Synonyms: gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; Signaling threshold-regulating transmembrane adapter 1; SIT; SIT1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1
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Gene Symbols: SIT1
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Molecular weight:
21,126 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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