|
SIT
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 9p13.3 |
|
Cellular Component:
plasma membrane
|
|
Molecular Function:
kinase binding; protein binding; SH2 domain binding
|
|
Biological Process:
adaptive immune response; regulation of T cell activation; signal transduction; T cell homeostasis
|
|
Reference #:
Q9Y3P8
(UniProtKB)
|
|
Alt. Names/Synonyms: gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP-2 interacting transmembrane adaptor protein; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; Signaling threshold-regulating transmembrane adapter 1; SIT; SIT-R; SIT1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1
|
|
Gene Symbols: SIT1
|
|
Molecular weight:
21,126 Da
|
|
Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
