EB1 Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. May play a role in cell migration. Belongs to the MAPRE family. Ubiquitously expressed. Note: This description may include information from UniProtKB.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of human Ortholog: 20q11.21

Cellular Component: cell projection membrane; centrosome; ciliary basal body; cortical microtubule cytoskeleton; cytoplasmic microtubule; cytosol; focal adhesion; Golgi apparatus; microtubule; microtubule organizing center; microtubule plus-end; mitotic spindle astral microtubule end; mitotic spindle pole; spindle; spindle midzone

Molecular Function: identical protein binding; microtubule plus-end binding; molecular adaptor activity; protein binding; protein kinase binding

Biological Process: attachment of mitotic spindle microtubules to kinetochore; cell division; cell migration; establishment of mitotic spindle orientation; microtubule bundle formation; microtubule polymerization; negative regulation of microtubule polymerization; non-motile cilium assembly; positive regulation of microtubule plus-end binding; positive regulation of microtubule polymerization; protein localization; protein localization to astral microtubule; protein localization to centrosome; protein localization to microtubule; regulation of microtubule polymerization or depolymerization; spindle assembly

Reference #: Q15691 (UniProtKB)

Alt. Names/Synonyms: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MAPRE1; MARE1; MGC117374; MGC129946; microtubule associated protein RP/EB family member 1; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1

Gene Symbols: MAPRE1

Molecular weight: 29,999 Da

Basal Isoelectric point: 5.02 Predict pI for various phosphorylation states

CST Pathways: Microtubule Dynamics

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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EB1

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