VCP an ATPase enzyme present in all eukaryotes and archaebacteria. Is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Is involved in vesicle transport and fusion, and in the formation of the transitional endoplasmic reticulum (tER). tER contains ER exit sites involved in the transfer of membranes from the endoplasmic reticulum to the Golgi apparatus. Vesicle budding from the tER is an ATP-dependent process. Is part of the complex containing NPLOC4-UFD1-VCP that binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex also regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP-AMFR complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced preemptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of the stress granule (SGs) clearance process upon arsenite-induced response. Involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; DNA repair, damage; EC; Endoplasmic reticulum; Hydrolase
Chromosomal Location of human Ortholog: 9p13.3
Cellular Component:  ATPase complex; azurophil granule lumen; cytoplasm; cytoplasmic stress granule; cytosol; Derlin-1 retrotranslocation complex; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; ficolin-1-rich granule lumen; glutamatergic synapse; intracellular membrane-bounded organelle; lipid droplet; nucleoplasm; nucleus; perinuclear region of cytoplasm; proteasome complex; protein-containing complex; secretory granule lumen; site of double-strand break; VCP-NPL4-UFD1 AAA ATPase complex; VCP-NSFL1C complex
Molecular Function:  ADP binding; ATP binding; ATPase activity; BAT3 complex binding; deubiquitinase activator activity; identical protein binding; K48-linked polyubiquitin modification-dependent protein binding; lipid binding; MHC class I protein binding; polyubiquitin modification-dependent protein binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding; ubiquitin-specific protease binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; ATP metabolic process; autophagosome maturation; autophagy; cellular response to arsenite ion; cellular response to DNA damage stimulus; cellular response to heat; DNA repair; double-strand break repair; endoplasmic reticulum stress-induced pre-emptive quality control; endoplasmic reticulum unfolded protein response; endosome to lysosome transport via multivesicular body sorting pathway; ER to Golgi vesicle-mediated transport; ER-associated misfolded protein catabolic process; ERAD pathway; error-free translesion synthesis; establishment of protein localization; flavin adenine dinucleotide catabolic process; macroautophagy; NADH metabolic process; neutrophil degranulation; positive regulation of ATP biosynthetic process; positive regulation of canonical Wnt signaling pathway; positive regulation of Lys63-specific deubiquitinase activity; positive regulation of mitochondrial membrane potential; positive regulation of oxidative phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein K63-linked deubiquitination; positive regulation of ubiquitin-specific protease activity; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein folding; protein hexamerization; protein homooligomerization; protein N-linked glycosylation via asparagine; protein ubiquitination; regulation of aerobic respiration; regulation of apoptotic process; regulation of synapse organization; retrograde protein transport, ER to cytosol; stress granule disassembly; translesion synthesis; transmembrane transport; ubiquitin-dependent ERAD pathway; viral genome replication
Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Charcot-marie-tooth Disease, Axonal, Type 2y; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1
Reference #:  P55072 (UniProtKB)
Alt. Names/Synonyms: 15S Mg(2+)-ATPase p97 subunit; CDC48; IBMPFD; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; Transitional endoplasmic reticulum ATPase; valosin containing protein; Valosin-containing protein; VCP; yeast Cdc48p homolog
Gene Symbols: VCP
Molecular weight: 89,322 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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