NCK1 Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component:  cell-cell junction; cytoplasm; cytosol; endoplasmic reticulum; nucleus; plasma membrane; protein phosphatase type 1 complex; ribosome; vesicle membrane
Molecular Function:  cytoskeletal adaptor activity; ephrin receptor binding; eukaryotic initiation factor eIF2 binding; protein binding; protein binding, bridging; protein domain specific binding; protein kinase inhibitor activity; receptor signaling complex scaffold activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity; signaling receptor binding
Biological Process:  actin filament organization; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; lamellipodium assembly; negative regulation of cell death; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; peptidyl-serine dephosphorylation; positive regulation of actin filament polymerization; positive regulation of cap-dependent translational initiation; positive regulation of cap-independent translational initiation; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; positive regulation of T cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of translation in response to endoplasmic reticulum stress; regulation of cell migration; response to other organism; signal complex assembly; substrate-dependent cell migration, cell extension; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P16333 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; NCK1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
Gene Symbols: NCK1
Molecular weight: 42,864 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein