TUBA4A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  cytoskeleton; cytosol; extracellular region; microtubule; microtubule cytoskeleton
Molecular Function:  GTPase activity; protein binding; protein kinase binding
Biological Process:  ciliary basal body-plasma membrane docking; G2/M transition of mitotic cell cycle; platelet degranulation; regulation of G2/M transition of mitotic cell cycle
Disease: Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia
Reference #:  P68366 (UniProtKB)
Alt. Names/Synonyms: Alpha-tubulin 1; ALS22; FLJ30169; H2-ALPHA; TBA4A; Testis-specific alpha-tubulin; TUBA1; TUBA4A; tubulin alpha 4a; Tubulin alpha-1 chain; Tubulin alpha-4A chain; Tubulin H2-alpha; tubulin, alpha 1 (testis specific); tubulin, alpha 4a
Gene Symbols: TUBA4A
Molecular weight: 49,924 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene