LPP May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Belongs to the zyxin/ajuba family. Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q27.3-q28
Cellular Component:  cytosol; focal adhesion; nucleus; plasma membrane
Molecular Function:  metal ion binding; protein binding
Biological Process:  cell adhesion
Disease: Leukemia, Acute Myeloid
Reference #:  Q93052 (UniProtKB)
Alt. Names/Synonyms: DKFZp779O0231; FLJ30652; FLJ41512; LIM domain containing preferred translocation partner in lipoma; LIM domain-containing preferred translocation partner in lipoma; LIM protein; lipoma preferred partner; Lipoma-preferred partner; LPP
Gene Symbols: LPP
Molecular weight: 65,746 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LPP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene