|
leupaxin
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. Belongs to the paxillin family. Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 11q12.1 |
|
Cellular Component:
cell projection; cytoplasm; cytosol; focal adhesion; nuclear speck; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome
|
|
Molecular Function:
metal ion binding; protein binding; transcription coregulator activity
|
|
Biological Process:
cell adhesion; DNA-templated transcription; endothelial cell migration; negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein-containing complex assembly; regulation of cell adhesion mediated by integrin; signal transduction; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
|
|
Reference #:
O60711
(UniProtKB)
|
|
Alt. Names/Synonyms: LDLP; LDPL; Leupaxin; LPXN
|
|
Gene Symbols: LPXN
|
|
Molecular weight:
43,332 Da
|
|
Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
