CD3Z Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). Belongs to the CD3Z/FCER1G family. CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs) (PubMed:11722641). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 1q24.2
Cellular Component:  alpha-beta T cell receptor complex; cytoplasm; Fc-gamma receptor III complex; gamma-delta T cell receptor complex; Golgi apparatus; plasma membrane; T cell receptor complex
Molecular Function:  identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase binding; transmembrane signaling receptor activity
Biological Process:  adaptive immune response; alpha-beta T cell activation; cell surface receptor signaling pathway; Fc-gamma receptor signaling pathway; gamma-delta T cell activation; positive regulation of protein localization to cell surface; protein-containing complex assembly; T cell receptor signaling pathway
Disease: Immunodeficiency 25
Reference #:  P20963 (UniProtKB)
Alt. Names/Synonyms: CD247; CD247 antigen, zeta subunit; CD247 molecule; CD3-ZETA; CD3H; CD3Q; CD3Z; CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; IMD25; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface glycoprotein CD3 zeta chain; T3Z; TCR zeta chain; TCRZ
Gene Symbols: CD247
Molecular weight: 18,696 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein