TfR Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. Belongs to the peptidase M28 family. M28B subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 3q29
Cellular Component:  basolateral plasma membrane; cell surface; clathrin-coated endocytic vesicle membrane; clathrin-coated pit; cytoplasmic vesicle; early endosome; endosome; endosome membrane; external side of plasma membrane; extracellular region; HFE-transferrin receptor complex; intracellular membrane-bounded organelle; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane
Molecular Function:  chaperone binding; double-stranded RNA binding; Hsp70 protein binding; identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; protein-containing complex binding; transferrin receptor activity; virus receptor activity
Biological Process:  acute-phase response; aging; cellular iron ion homeostasis; cellular response to leukemia inhibitory factor; cellular response to xenobiotic stimulus; intracellular signal transduction; iron ion transport; negative regulation of apoptotic process; negative regulation of mitochondrial fusion; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of isotype switching; positive regulation of NF-kappaB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of protein-containing complex assembly; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell population proliferation; response to copper ion; response to hypoxia; response to iron ion; response to manganese ion; response to nutrient; response to retinoic acid; transferrin transport; transport across blood-brain barrier; viral entry into host cell
Disease: Immunodeficiency 46
Reference #:  P02786 (UniProtKB)
Alt. Names/Synonyms: CD71; IMD46; p90; sTfR; T9; TfR; TfR1; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols: TFRC
Molecular weight: 84,871 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TfR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein