TfR Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. Belongs to the peptidase M28 family. M28B subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 3q29
Cellular Component:  basolateral plasma membrane; cell surface; clathrin-coated pit; clathrin-coated vesicle membrane; cytoplasmic vesicle; early endosome; endosome; endosome membrane; external side of plasma membrane; extracellular region; HFE-transferrin receptor complex; integral component of plasma membrane; melanosome; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function:  double-stranded RNA binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity; virus receptor activity
Biological Process:  cellular iron ion homeostasis; cellular response to drug; cellular response to leukemia inhibitory factor; iron ion transport; membrane organization; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; transferrin transport; viral entry into host cell
Disease: Immunodeficiency 46
Reference #:  P02786 (UniProtKB)
Alt. Names/Synonyms: CD71; p90; sTfR; T9; TfR; TfR1; TFRC; transferrin receptor (p90, CD71); Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols: TFRC
Molecular weight: 84,871 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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