TAFII31 Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Belongs to the TAF9 family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of human Ortholog: 5q13.2
Cellular Component:  MLL1 complex; nucleoplasm; nucleus; pre-snoRNP complex; SAGA complex; transcription factor TFIID complex; transcription factor TFTC complex
Molecular Function:  ATPase binding; C2H2 zinc finger domain binding; DNA binding; DNA-binding transcription factor binding; histone acetyltransferase activity; p53 binding; protein binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; transcription cis-regulatory region binding; transcription coactivator activity
Biological Process:  box C/D snoRNP assembly; chromatin remodeling; DNA damage response; histone acetylation; histone H3 acetylation; monoubiquitinated histone deubiquitination; monoubiquitinated histone H2A deubiquitination; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of DNA-templated transcription; positive regulation of response to cytokine stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein phosphorylation; protein stabilization; regulation of DNA repair; regulation of DNA-templated transcription; regulation of RNA splicing; regulation of transcription by RNA polymerase II; response to interleukin-1; response to L-glutamate; RNA polymerase II preinitiation complex assembly
Reference #:  Q16594 (UniProtKB)
Alt. Names/Synonyms: MGC:5067; RNA polymerase II TBP-associated factor subunit G; STAF31/32; TAF2G; TAF9; TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa; TAFII-31; TAFII-32; TAFII31; TAFII32; TAFIID32; TATA-box binding protein associated factor 9; transcription initiation factor TFIID 31 kD subunit; Transcription initiation factor TFIID 31 kDa subunit; Transcription initiation factor TFIID 32 kDa subunit; Transcription initiation factor TFIID subunit 9
Gene Symbols: TAF9
Molecular weight: 28,974 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

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