VPS18 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in dendrite development of Pukinje cells. Belongs to the VPS18 family. Ubiquitous. Expression was highest in heart and low in lung. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component:  actin filament; AP-3 adaptor complex; autophagosome; clathrin-coated vesicle; CORVET complex; early endosome; glutamatergic synapse; HOPS complex; late endosome; late endosome membrane; lysosome; presynapse
Molecular Function:  actin binding; metal ion binding; protein binding; syntaxin binding
Biological Process:  autophagy; endosome organization; endosome to lysosome transport; intracellular protein transport; lysosome organization; regulation of synaptic vesicle exocytosis; viral entry into host cell
Reference #:  Q9P253 (UniProtKB)
Alt. Names/Synonyms: hVPS18; KIAA1475; PEP3; vacuolar protein sorting 18 homolog; vacuolar protein sorting 18 homolog (S. cerevisiae); vacuolar protein sorting protein 18; Vacuolar protein sorting-associated protein 18 homolog; VPS18; VPS18 core subunit of CORVET and HOPS complexes; VPS18, CORVET/HOPS core subunit
Gene Symbols: VPS18
Molecular weight: 110,186 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB