TRPT1 Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. Belongs to the KptA/TPT1 family. Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.160; Transferase
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: 
Molecular Function:  tRNA 2'-phosphotransferase activity
Biological Process:  regulation of protein kinase activity; tRNA splicing, via endonucleolytic cleavage and ligation
Reference #:  Q86TN4 (UniProtKB)
Alt. Names/Synonyms: MGC11134; tRNA 2'-phosphotransferase 1; tRNA phosphotransferase 1; tRNA splicing 2' phosphotransferase 1; TRPT1
Gene Symbols: TRPT1
Molecular weight: 27,742 Da
Basal Isoelectric point: 10.01  Predict pI for various phosphorylation states
Select Structure to View Below

TRPT1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene