TMEM206
Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling. Belongs to the proton-activated chloride channel family. Widely expressed, with highest expression in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of mouse Ortholog: 1|1 H6 |
Cellular Component:
chloride channel complex; membrane; plasma membrane
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Molecular Function:
chloride channel activity; pH-gated chloride channel activity
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Biological Process:
chloride transport; monoatomic ion transport
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Reference #:
Q9D771
(UniProtKB)
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Alt. Names/Synonyms: 2310028N02Rik; AI118576; PAC; PACC1; proton activated chloride channel 1; Proton-activated chloride channel; TM206; Tmem206; Transmembrane protein 206
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Gene Symbols: Pacc1
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Molecular weight:
40,178 Da
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Basal Isoelectric point:
7.62
Predict pI for various phosphorylation states
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