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TFAM
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription regulation |
| Chromosomal Location of human Ortholog: 10q21.1 |
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Cellular Component:
cytosol; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; protein-containing complex
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Molecular Function:
chromatin binding; heat shock protein binding; mitochondrial promoter sequence-specific DNA binding; mitochondrial transcription factor activity; protein binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coactivator binding
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Biological Process:
mitochondrial respiratory chain complex assembly; mitochondrial transcription; positive regulation of DNA-templated transcription; transcription initiation at mitochondrial promoter
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Disease: Mitochondrial Dna Depletion Syndrome 15 (hepatocerebral Type)
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Reference #:
Q00059
(UniProtKB)
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Alt. Names/Synonyms: Mitochondrial transcription factor 1; mitochondrial transcription factor A; MTDPS15; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; Transcription factor 6; transcription factor 6-like 1; Transcription factor 6-like 2; Transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor 6-like 3; Transcription factor A, mitochondrial
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Gene Symbols: TFAM
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Molecular weight:
29,097 Da
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Basal Isoelectric point:
9.74
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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