snRNP D2 Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. Belongs to the snRNP core protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: RNA splicing; Spliceosome

Chromosomal Location of human Ortholog: 19q13.32

Cellular Component: catalytic step 2 spliceosome; cytosol; methylosome; nucleoplasm; nucleus; pICln-Sm protein complex; precatalytic spliceosome; small nuclear ribonucleoprotein complex; SMN-Sm protein complex; spliceosomal complex; U1 snRNP; U12-type spliceosomal complex; U2 snRNP; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome; U4 snRNP; U4/U6 x U5 tri-snRNP complex; U5 snRNP

Molecular Function: protein binding; U1 snRNP binding

Biological Process: 7-methylguanosine cap hypermethylation; mRNA splicing, via spliceosome; RNA splicing; spliceosomal complex assembly; spliceosomal snRNP assembly; U2-type prespliceosome assembly

Reference #: P62316 (UniProtKB)

Alt. Names/Synonyms: Sm-D2; small nuclear ribonucleoprotein D2 polypeptide; small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; Small nuclear ribonucleoprotein Sm D2; SMD2; snRNP core protein D2; snRNP D2; SNRPD1; SNRPD2

Gene Symbols: SNRPD2

Molecular weight: 13,527 Da

Basal Isoelectric point: 9.92 Predict pI for various phosphorylation states

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snRNP D2

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