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SIRT6
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Belongs to the sirtuin family. Class IV subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
chromatin; chromosome, subtelomeric region; endoplasmic reticulum; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; pericentric heterochromatin; site of DNA damage; site of double-strand break
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Molecular Function:
chromatin binding; chromatin DNA binding; damaged DNA binding; DNA damage sensor activity; lncRNA binding; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD+- protein-lysine ADP-ribosyltransferase activity; NAD+-protein ADP-ribosyltransferase activity; NAD+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent histone H3K18 deacetylase activity; NAD-dependent histone H3K56 deacetylase activity; NAD-dependent histone H3K9 deacetylase activity; NAD-dependent protein deacetylase activity; NAD-dependent protein demyristoylase activity; NAD-dependent protein depalmitoylase activity; nucleosome binding; nucleotidyltransferase activity; protein binding; protein homodimerization activity; TORC2 complex binding; transcription corepressor activity; zinc ion binding
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Biological Process:
base-excision repair; cardiac muscle cell differentiation; circadian regulation of gene expression; determination of adult lifespan; DNA repair-dependent chromatin remodeling; double-strand break repair; glucose homeostasis; histone deacetylation; ketone biosynthetic process; negative regulation of cell population proliferation; negative regulation of cellular senescence; negative regulation of gene expression, epigenetic; negative regulation of gluconeogenesis; negative regulation of glucose import; negative regulation of glycolytic process; negative regulation of protein import into nucleus; negative regulation of protein localization to chromatin; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; pericentric heterochromatin formation; positive regulation of blood vessel branching; positive regulation of chondrocyte proliferation; positive regulation of cold-induced thermogenesis; positive regulation of double-strand break repair; positive regulation of fat cell differentiation; positive regulation of fibroblast proliferation; positive regulation of histone deacetylase activity; positive regulation of insulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein export from nucleus; positive regulation of protein localization to chromatin; positive regulation of stem cell differentiation; positive regulation of stem cell population maintenance; positive regulation of stem cell proliferation; positive regulation of telomere maintenance; positive regulation of vascular endothelial cell proliferation; post-translational protein modification; protein deacetylation; protein delipidation; protein destabilization; protein localization to site of double-strand break; regulation of circadian rhythm; regulation of double-strand break repair via homologous recombination; regulation of lipid catabolic process; regulation of lipid metabolic process; regulation of protein localization to plasma membrane; regulation of protein secretion; response to UV; retrotransposon silencing; subtelomeric heterochromatin formation
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Reference #:
Q8N6T7
(UniProtKB)
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Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; sir2-related protein type 6; SIR2L6; SIR6; SIRT6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6; sirtuin type 6
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Gene Symbols: SIRT6
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Molecular weight:
39,119 Da
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Basal Isoelectric point:
9.31
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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