SHARPIN Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  cell junction; cytosol; dendrite; LUBAC complex; postsynaptic density
Molecular Function:  identical protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein-containing complex binding
Biological Process:  apoptotic nuclear changes; brain development; I-kappaB kinase/NF-kappaB signaling; keratinization; mitochondrion organization; negative regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein homooligomerization; protein linear polyubiquitination; regulation of CD40 signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway
Reference #:  Q9H0F6 (UniProtKB)
Alt. Names/Synonyms: DKFZp434N1923; hSIPL1; SHANK associated RH domain interactor; SHANK-associated RH domain interactor; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; Sharpin; SHRPN; SIPL1
Gene Symbols: SHARPIN
Molecular weight: 39,949 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene