RAB3GAP1
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Belongs to the Rab3-GAP catalytic subunit family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Chromosomal Location of mouse Ortholog: 1|1 E3 |
Cellular Component:
cytoplasm; endoplasmic reticulum; endoplasmic reticulum tubular network; excitatory synapse; Golgi apparatus; lipid droplet; protein-containing complex
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Molecular Function:
GTPase activator activity; guanyl-nucleotide exchange factor activity; small GTPase binding
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Biological Process:
brain development; camera-type eye development; establishment of protein localization to endoplasmic reticulum membrane; excitatory postsynaptic potential; face morphogenesis; hypothalamus development; lipid droplet organization; positive regulation of autophagosome assembly; positive regulation of endoplasmic reticulum tubular network organization; positive regulation of gene expression; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization; positive regulation of GTPase activity; positive regulation of protein lipidation; protein stabilization; regulation of calcium ion-dependent exocytosis of neurotransmitter; regulation of GTPase activity; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle priming; synaptic vesicle transport
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Reference #:
Q80UJ7
(UniProtKB)
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Alt. Names/Synonyms: 1700003B17Rik; 4732493F09Rik; AL117896; Kiaa0066; OTTMUSP00000030575; p13; p130; RAB3 GTPase activating protein subunit 1; RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic subunit; Rab3-GAP; Rab3-GAP p130; Rab3gap; Rab3gap1; RB3GP
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Gene Symbols: Rab3gap1
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Molecular weight:
110,198 Da
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Basal Isoelectric point:
5.5
Predict pI for various phosphorylation states
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