PRDX1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component:  cytoplasm; cytosol; melanosome; nucleus
Molecular Function:  identical protein binding; peroxidase activity; protein binding; thioredoxin peroxidase activity
Biological Process:  cell proliferation; cellular response to oxidative stress; erythrocyte homeostasis; hydrogen peroxide catabolic process; natural killer cell activation; natural killer cell mediated cytotoxicity; oxidation-reduction process; regulation of NIK/NF-kappaB signaling; regulation of stress-activated MAPK cascade; skeletal system development
Disease: Methylmalonic Aciduria And Homocystinuria, Cblc Type
Reference #:  Q06830 (UniProtKB)
Alt. Names/Synonyms: MSP23; Natural killer cell-enhancing factor A; natural killer-enhancing factor A; NKEF-A; NKEFA; PAG; PAGA; PAGB; peroxiredoxin 1; Peroxiredoxin-1; PRDX1; proliferation-associated gene A; Proliferation-associated gene protein; PRX1; PRXI; TDPX2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
Gene Symbols: PRDX1
Molecular weight: 22,110 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein