PLA2G3
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) Belongs to the phospholipase A2 family. Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level). Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase |
Chromosomal Location of human Ortholog: 22q12.2 |
Cellular Component:
centriole; extracellular region; extracellular space; plasma membrane; recycling endosome
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Molecular Function:
calcium-dependent phospholipase A2 activity; metal ion binding
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Biological Process:
acrosome assembly; arachidonic acid secretion; cell maturation; cilium assembly; high-density lipoprotein particle remodeling; lipoxygenase pathway; low-density lipoprotein particle remodeling; macrophage activation; mast cell degranulation; negative regulation of amyloid-beta clearance; negative regulation of gene expression; negative regulation of neuron apoptotic process; phosphatidic acid metabolic process; phosphatidylcholine metabolic process; phosphatidylethanolamine metabolic process; phosphatidylglycerol metabolic process; phosphatidylinositol metabolic process; phosphatidylserine metabolic process; phospholipid metabolic process; positive regulation of cytokine production involved in inflammatory response; positive regulation of histamine secretion by mast cell; positive regulation of macrophage derived foam cell differentiation; positive regulation of mast cell differentiation; positive regulation of neuron projection development; positive regulation of prostaglandin biosynthetic process; positive regulation of prostaglandin secretion; production of molecular mediator involved in inflammatory response; regulation of endocytic recycling; sperm axoneme assembly
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Reference #:
Q9NZ20
(UniProtKB)
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Alt. Names/Synonyms: GIII sPLA2; GIII-SPLA2; Group 3 secretory phospholipase A2; group III secreted phospholipase A2; Group III secretory phospholipase A2; PA2G3; Phosphatidylcholine 2-acylhydrolase 3; phosphatidylcholine 2-acylhydrolase GIII; phospholipase A2 group III; phospholipase A2, group III; PLA2G3; sPLA2-III; SPLA2III
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Gene Symbols: PLA2G3
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Molecular weight:
57,167 Da
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Basal Isoelectric point:
9.35
Predict pI for various phosphorylation states
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