PHGDH Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p12
Cellular Component:  cytosol
Molecular Function:  electron transfer activity; L-malate dehydrogenase activity; NAD binding
Biological Process:  brain development; electron transport chain; G1 to G0 transition; gamma-aminobutyric acid metabolic process; glial cell development; glutamine metabolic process; glycine metabolic process; L-serine biosynthetic process; neural tube development; neuron projection development; regulation of gene expression; spinal cord development; taurine metabolic process; threonine metabolic process
Disease: Neu-laxova Syndrome 1; Phosphoglycerate Dehydrogenase Deficiency
Reference #:  O43175 (UniProtKB)
Alt. Names/Synonyms: 3-PGDH; 3-phosphoglycerate dehydrogenase; 3PGDH; D-3-phosphoglycerate dehydrogenase; MGC3017; PDG; PGAD; PGD; PGDH; PGDH3; PHGDH; phosphoglycerate dehydrogenase; SERA
Gene Symbols: PHGDH
Molecular weight: 56,650 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PHGDH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene