MTF2 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter. Belongs to the Polycomblike family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component:  cytoplasm; focal adhesion; nucleoplasm; nucleus
Molecular Function:  metal ion binding; methylated histone binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  cellular response to leukemia inhibitory factor; chromatin organization; negative regulation of gene expression, epigenetic; negative regulation of histone H3-K27 methylation; negative regulation of transcription by RNA polymerase II; positive regulation of histone H3-K27 methylation; positive regulation of transcription by RNA polymerase II; segment specification; stem cell differentiation; stem cell population maintenance
Reference #:  Q9Y483 (UniProtKB)
Alt. Names/Synonyms: dJ976O13.2; hPCl2; M96; Metal regulatory transcription factor 2; metal response element binding transcription factor 2; metal response element-binding transcription factor 2; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; MTF2; PCL2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RP5-976O13.1; TDRD19A; tudor domain containing 19A
Gene Symbols: MTF2
Molecular weight: 67,106 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene